Effect of Low Frequency Ultrasound on Kidney Function

N/ACompletedNCT02026544

Sonogenix10 enrolled

Overview

The purpose of this study is to find out what effect, if any, Low Frequency Therapeutic Ultrasound (LOTUS) has on kidney function in patients with chronic kidney disease.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Chronic Kidney Disease

Interventions

Low Frequency Therapeutic UltrasoundDEVICE

29 kHz (kilohertz) low frequency therapeutic ultrasound delivered transcutaneously

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Must be \>/= 18 years of age * Must have documented Stage 3 to Stage 4 (eGFR 15 - 59) chronic kidney disease * Females with childbearing potential must not be pregnant at the time of study * Subject must provide written informed consent Exclusion Criteria: * Unable or unwilling to cooperate with study procedures * Currently enrolled in another clinical study for which the follow-up period is not complete

Locations (1)

Department of Radiology and Biomedical Imaging, UCSF

San Francisco, California, United States

Outcomes

Primary Outcomes

Glomerular Filtration Rate (GFR)

Absolute change in glomerular filtration rate, GFR, measured by Tc-99m DTPA (diethylenetriamine pentaacetic acid) imaging (Gates Method) in the treated kidney(s) from baseline to during LOTUS

Time frame: Baseline and 15 minutes after start of Intervention

Secondary Outcomes

Percent change in GFR

Percent change in GFR in the treated kidney(s) from baseline to during LOTUS.

Time frame: Baseline and 15 minutes after start of Intervention

Blood Pressure

Blood pressure is measured at baseline, during LOTUS intervention, and immediately after LOTUS intervention

Time frame: Baseline and 15 minutes after start of Intervention, and 5 minutes after end of intervention

Data from ClinicalTrials.gov

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