Comparative Study of Physiological and Cerebrovascular Reactivity in Depression, at the Three Phases of Emotion

Inclusion Criteria: * Female between 18 and 55 * Informed consent form signed * Affiliated to a medical insurance * visual and hearing abilities suitable for exams * for the depressive group (group D): major depressive disorder according to the DSM-IV criteria as evaluated by the MINI test and MADRS score ≥22 * for the depressive patients in remission's group (group R) : matched on age, at least 1 history of major depressive disorder in the last 10 years and solved for more than 6 months, and MADRS score \< 9 * for the control subjects (group T) : matched on age, no psychiatric history, MADRS score \< 9 Exclusion Criteria: * psychotic disorder, bipolar disorder, addiction, suspected dementia (MMSE\<25) * current betablockers or neuroleptics treatment * any current organic unstable pathology * history of serious cardiovascular disease (coronary syndrome, cardiac arrythmia, etc.) * smoking \> 10 PY * history of serious neurologic disease (stroke, cerebral tumour, serious cranial trauma, headache, ...) * contra-indication to MRI * uncorrected vision or audition troubles * patient under juridic protection * pregnancy, lactating or female without reliable contraception