RNA Extraction and Amplification From Biopsy Specimens in Subjects With Metastatic Renal Cell Carcinoma (AGS-NTS-017)

Inclusion Criteria: A subject with metastatic RCC, who in the opinion of the treating physician, is a potential candidate for inclusion in this study if all of the following criteria apply: 1. 18 years of age or older. 2. Suspected RCC, in the opinion of the investigator 3. Availability of either: * Nephrectomy or other surgically removed tissue (Stage I); or, * Metastatic RCC biopsy tissue utilizing needle or core biopsy procedures (Stage II). 4. ≥5 biopsy specimens available from BRPC. * Subjects who are having a surgical procedure (i.e. metastasectomy, nephrectomy) will have these core biopsies obtained from the surgical specimen, per the BRPC protocol. 5. Not currently being treated with systemic therapy. Exclusion Criteria: 1. Tumor tissue is committed to other use or inadequate for RNA analysis. 2. Insufficient tissue is collected in the BRPC. Expansion Cohort for Genitourinary Cancers: Inclusion Criteria: 1. 18 years of age or older 2. Suspected bladder, prostate, or testicular cancer, in the opinion of the investigator. 3. Availability of surgically removed tissue or biopsy tissue. 4. At least 2 biopsy specimens available from BRPC 5. Not currently being treated with systemic therapy. Exclusion Criteria: 1. Tumor tissue is committed to other use or inadequate for RNA analysis. 2. Insufficient tissue is collected in the BRPC.