Traumatic Neuroprotection and Epilepsy Prevention of Valproate Acid

Inclusion Criteria: * Eligible patients were 16 to 65 years of age with all genders. * The patients had sustained a nonpenetrating traumatic brain injury 4 to 16 weeks before enrollment, with the confirmation of CT or MRI. * Additional eligibility criteria were a vegetative state or a minimally conscious state, as indicated by a Disability Rating Scale (DRS) score greater than 11. * There was an inability both to follow commands consistently and to engage in functional communication, as assessed by the score on the Coma Recovery Scale-Revised (CRS-R) * All the patients had provided written informed consent. * The patients were receiving usual inpatient rehabilitation and treatment at each site. Exclusion Criteria: * unstable health state,including:Be allergic to VPA, or with serious allergic diseases or allergic constitutions;With serious cardiovascular diseases, hepatic, renal, or psychiatric diseases;With serious respiratory, endocrine, or blood system diseases;With serious infections or malignant tumors; With weakened immunologic status;Addison's diseases;With alcohol or drug abuse. * Any disability related to the central nervous system that predated the traumatic brain injury. * Pregnancy or breastfeeding females. * More than one seizure in the previous month. * Prior treatment with VPA * In the case of patients who were undergoing evaluation for ventricular shunt placement or receiving a psychoactive medication, enrollment was deferred until shunt placement had been completed or psychoactive medications discontinued. * The patients had enrolled the other studies in the past three months or are engaging the other studies. * The patients were assessed as unqualified for the study according to the comprehensive evaluation opinion brought forward by the research team.