Clinical Evaluation of Lyral® Dose Response Study

Inclusion Criteria: 1. Males and females 18 years of age and older. 2. Clinical history of contact dermatitis and positive patch test (current or previous) to either Lyral® or Fragrance Mix 2; otherwise in good general health. 3. Unable to become pregnant or willing to use an acceptable method of contraception to prevent pregnancy if female of childbearing potential; Inability to become pregnant would include all male subjects and female subjects who are postmenopausal for at least 1 year, or surgically sterile- have had a hysterectomy, bilateral ovariectomy, uterine ablation or bilateral tubal ligation. Acceptable methods of contraception include: 1) systemic birth control (the same type of birth control for at least 3 months prior to entering the study and continuation of this type of birth control throughout the study); 2) double barrier methods (condom with spermicide or diaphragm with spermicide); 3) intra uterine device; 4) vasectomized partner; or 5) abstinence from sexual intercourse. 4. Have read and signed the consent form and are able to fulfill the study requirements and make all required visits. Exclusion Criteria: 1. Lactation or pregnancy, determined by urine pregnancy test (UPT) for females of childbearing potential. UPT must be conducted prior to patch placement. 2. Treatment with topical corticosteroids on or near the test area during the previous 7 days. 3. Treatment with systemic corticosteroids or immunosuppressives during the previous 7 days. (Inhaled treatments are permitted.) 4. Treatment with ultraviolet (UV) light, including tanning, during the previous 3 weeks. 5. Acute dermatitis outbreak or dermatitis on or near the test area on the back. 6. Participation in another clinical study involving an investigational drug, treatment or device currently or within the previous 3 weeks. 7. Unable to comply with activity restrictions (e.g., protecting test panels from excess moisture due to showering or vigorous activity). 8. Unable or unwilling to comply with multiple return visits.