This study will compare two alternative embryo culture systems. Embryos from each patient will be randomly assigned to one of two systems. One group will be cultured conventionally in oil-covered droplets in dishes. The other group will be assigned to an enclosed system.
Qualifying and consenting IVF patients will have approximately half of their developing embryos cultured in droplets covered with oil. The other approximate half of their embryos will be cultured in small enclosed containers. Embryo assignments will be at random. Regardless of culture system, all embryos will be cultured from the bipronuclear stage to the blastocyst stage in the same (Global) media, without the usual refreshing of media on day 3.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Fertility Center of Las Vegas
Las Vegas, Nevada, United States
Blastulation rate
Proportion of cultured embryos that form blastocysts.
Time frame: 5 days (sixth day of embryo development)
Blastocyst morphology
Inner cell mass size, number of trophectoderm cells, blastocyst diameter
Time frame: 5 days (sixth day of development)
IVF outcome
The result of the IVF cycle as no pregnancy, early pregnancy loss, or ongoing pregnancy at 10 weeks gestation (about 7 weeks post-transfer).
Time frame: 7 weeks post-transfer
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