Hypothesis: acupoint application is effective for managing chronic stable angina pectoris. Aim: to evaluate the efficacy and safety of acupoint application on the specific acupoints for chronic stable angina pectoris. Design: A Randomized, Controlled,Double Blind trial. 200 participants will be included. Four arms: herbal medicine application on acupoint group , placebo application on acupoint group , herbal medicine application on non-acupoint group and placebo application on non-acupoint group.
Acupoint application with herbal medicine is a kind of external treatment of traditional Chinese medicine and has a long history in China, which is use herbal medicine made of plaster and stick to specific acupoints, using the double effects of acupoints and herb to treat disease. In China, acupoint application with herbal medicine has been used in clinical treatment of angina pectoris, but there is no convincing evidence for the efficacy of acupoint application for angina pectoris, due to low methodologic quality and small sample size. The investigators designed the Randomized, Controlled, Double Blind clinical trial to investigates the efficacy of acupoint application in treating angina pectoris, the purpose of this study is to provide the convincing evidence for acupoint application treatment of angina pectoris.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
200
Application containing herbal medicine that mainly include styrax, borneol, frankincense, santalum,trichosanthes kirilowii Maxim, allium macrostemon Bunge, leech and other herbal medicine.
select acupoint according to traditional Chinese medicine
foundation treatment
Affiliated hospital of Chengdu University of TCM
Chengdu, Sichuan, China
Change from Baseline Number of angina attacks at 12 weeks
The change frequency of angina attack during every 4-week.
Time frame: at baseline,4, 8weeks after inclusion
Change from Baseline the severity of angina ( VAS score) at 12 weeks
The VAS score evaluation angina pain severity
Time frame: at baseline,4, 8weeks after inclusion
Change from Baseline the dosage of nitroglycerin at 12 weeks
Observed reduction in the dose of nitroglycerin
Time frame: at baseline,4, 8weeks after inclusion
Seattle Angina Questionnaire
Time frame: at baseline,4, 8weeks after inclusion
self-rating anxiety scale
Time frame: at baseline,4, 8weeks after inclusion
Self-rating Depression Scale
Time frame: at baseline,4, 8weeks after inclusion
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