The present study aims to compare directly the efficacy of two noninvasive neurostimulation techniques : repetitive transcranial magnetic stimulation and transcranial direct electrical current of the motor cortex in patients with chronic lumbar radiculopathy on pain intensity.
The present study ims to compare directly the efficacy of two noninvasive neurostimulation techniques : repetitive transcranial magnetic stimulation (rTMS) and transcranial direct electrical current (tDCS) of the motor cortex in patients with chronic lumbar radiculopathy on average pain intensity. This will be a sham controlled crossover design : patients will be randomized to receive either active rTMS or tDCS during 3 consecutive days followed by the alternative treatment within 3 weeks apart, or sham rTMS or tDCS during 3 consecutive dats followed by the alternative treatment within 3 weeks apart. The investigator will be blind to the treatment. Assessments will be performed before each treatment, then 1 hour after the end of the third day session, then 2 days and 1 week after the stimulation. Assessments will include pain questionnaires, quality of life, anxiety and depression, catastrophizing and evaluation of treatment effect on experimental pain using Quantitative sensory testing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
35
Hôpital Ambroise Paré
Boulogne-Billancourt, France
Hôpital Henri Mondor, APHP
Créteil, France
Comparison of rTMS and tDCS on average pain intensity
Average pain intensity numerical scales (0-10)
Time frame: 7 days after 3 days of stimulation
Comparison of rTMS and sham stimulation on average pain intensity
numerical scale for pain intensity (0-10)
Time frame: 7 days after 3 stimulation days
comparison of tDCS and sham stimulation on average pain intensity
numerical scales for pain intensity (0-10)
Time frame: at 7 days after 3 days of stimulation
comparison of rTMS and tDCS on current pain
pain intensity (right now)1 hour after each stimulation
Time frame: 1 hour after each stimulation session
comparison of rTMS and tDCS on pain intensity
numerical score (0-10) for pain over the last 24 hours
Time frame: 2 days after 3 stimulation days
comparison of rTMS versus tDCS and versus sham on BPI interference
BPI interference scale (0-70)
Time frame: 7 days after the end of 3 stimulation days
comparison of rTMS versus tDCS and sham on pain catastrophizing
Pain catastrophizing scale (PCS)
Time frame: 7 days after the last day of stimulation (3 days)
comparison of rTMS versus tDCS and sham on anxiety and depression
Hospital anxiety and depression scale
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Time frame: 7 days after the end of stimulation sessions
comparison of rTMS versus tDCS and sham on neuropathic symptoms
Neuropathic pain symptom inventory
Time frame: 7 days after the end of stimulations
comparison of rTMS versus tDCS and sham on thermal testing
thermal testing using thermotest on the upper limbs
Time frame: 2 days and 7 days after stimulation days
comparison of safety between rTMS and tDCS and between neurostimulation and sham
any emerging side effects
Time frame: immediately after each stimulation, then at 2 days and 7 days