Metabolism and Excretion of [14C]-Rigosertib After Infusion to Volunteers

Inclusion Criteria: * Body mass index (BMI) between 18.5 kg/m2 and 29.9 kg/m2, inclusive; * In good health, as defined by the absence of clinically significant findings from medical history, 12-lead electrocardiogram (ECG), and vital signs; * Clinical laboratory evaluations that are within the normal range, unless deemed not clinically significant by the Investigator. Platelet (PLT) count, white blood cell (WBC) count, and absolute neutrophil count (ANC) should all be above the lower limit of normal (LLN); * Negative test for selected drugs of abuse at Screening (does not include alcohol) and at Check-in (does include alcohol); * Negative hepatitis panel (including hepatitis B surface antigen \[HBsAg\] and hepatitis C virus antibody \[anti-HCV\]) and negative human immunodeficiency virus (HIV) antibody screens; * Males will either be vasectomized or sterile; * Female subjects must have undergone confirmed tubal ligation or hysterectomy or be post-menopausal; * Able to comprehend and willing to sign an informed consent form (ICF); * History of a minimum of 1 bowel movement per day. Exclusion Criteria: * Participation in any other investigational study drug trial in which receipt of an investigational agent, biologic agent, small targeted molecule, or immunotherapy occurred within 5 half-lives or 4 weeks of enrollment, whichever is longer; * Major surgery within 3 weeks of enrollment or major surgery without full recovery; * History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs except that appendectomy and hernia repair will be allowed; * Significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder; * History of Gilbert's Syndrome; * History or presence of an abnormal ECG, which, in the Investigator's opinion, is clinically significant; * Uncontrolled hypertension, defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, unless deemed acceptable by the Investigator; * History of seizures, except febrile seizures as a child; * Psychiatric illness/social situations that would limit the subject's ability to tolerate and/or comply with study requirements, or inability to comply with study and/or follow-up procedures; * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the Investigator; * History of alcoholism or drug addiction within 1 year prior to Check-in; * Participation in more than 1 other radiolabeled investigational study drug trial within 12 months prior to Check-in. The previous radiolabeled study drug must have been received more than 6 months prior to Check-in for this study and the total exposure from this study and the previous study will be within the recommended levels considered safe; * Exposure to significant radiation within 12 months prior to Check-in; * Use of any prescription medications/products within 14 days prior to Check-in, unless deemed acceptable by the Investigator; * Use of any over-the-counter, non-prescription preparations within 7 days prior to Check-in, unless deemed acceptable by the Investigator; * Poor peripheral venous access; * Donation of blood from 30 days prior to Screening through discharge, inclusive, or of plasma from 2 weeks prior to Screening through discharge, inclusive; * Receipt of blood products within 2 months prior to Check-in; * Any acute or chronic condition that, in the opinion of the Investigator, would limit the subject's ability to complete and/or participate in this clinical study.