Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patients With Chemotherapy Resistant or Refractory Acute Lymphoblastic Leukemia

Inclusion Criteria * Signed informed consent form must be obtained prior to any study procedure * Relapsed or refractory B-cell ALL 1. 1st or greater BM relapse OR 2. Any marrow relapse after allogeneic HSCT and \> 100 days from transplant OR 3. For patients with refractory disease: i. \< 60 years old that have not achieved a CR after \> 2 or more chemotherapy regimens ii. \>60 years old that have not achieved a CR after 1 prior chemotherapy regimen d. Patients with Ph+ ALL are eligible if they have failed tyrosine kinase inhibitor therapy * Documentation of CD19 tumor expression in bone marrow or peripheral blood by flow cytometry within 3 months of screening. * Adequate organ function defined as: 1. Creatinine \< 1.6 mg/dl 2. ALT/AST \< 3x upper limit of normal range 3. Direct bilirubin \<2.0 mg/dl 4. Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea, pulse oxygen \> 92% on room air, and DLCO \> 40% (corrected for anemia if clinically appropriate) 5. Left Ventricle Ejection Fraction (LVEF) ≥ 40% confirmed by ECHO/MUGA * Bone marrow with ≥ 5% lymphoblasts * Male or female age ≥ 18 years * A ECOG Performance Status that is either 0 or 1 * No contraindications for leukapheresis. Retreatment Inclusion Criteria * Performance Status 0-1 * Adequate organ system function including: * Creatinine \< 1.6 mg/dl * ALT/AST \< 3x upper limit of normal * Total Bilirubin \< 2.0 mg/dl * Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea, pulse oxygen \> 92% on room air, and DLCO \> 40% (corrected for anemia if clinically appropriate) * Left Ventricular Ejection Fraction ≥ 40% * No contraindications for leukapheresis (if required for retreatment) * Gives voluntary informed consent for retreatment Exclusion Criteria * Isolated extramedullary disease relapse * Active hepatitis B or active hepatitis C * Class III/IV cardiovascular disability according to the New York Heart Association Classification * HIV infection * Active acute or chronic graft-versus-host disease (GVHD) or requirement of immunosuppressant medications for GVHD within 4 weeks of enrollment. * Concurrent use of systemic steroids or chronic use of immunosuppressant medications. Recent or current use of inhaled steroids is not exclusionary. For additional details regarding use of steroid and immunosuppressant medications. * Active CNS involvement by malignancy. Note: Patients with history of CNS disease that has been effectively treated will be eligible provided that treatment was \>4 weeks before enrollment * Pregnant or nursing (lactating) women, female study participants of reproductive potential must have a negative serum or urine pregnancy test within 48 hours before infusion * Participation in a prior investigational study within 4 weeks prior to enrollment or longer if required by local regulation. Participation in non-therapeutic research studies is allowed. * Patients with a known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the central nervous system. Retreatment Exclusion Criteria * Pregnant or lactating women. * Active hepatitis B or hepatitis C * Concurrent use of systemic steroids or chronic use of immunosuppressant medications. Recent or current use of inhaled steroids is not exclusionary. For additional details regarding use of steroid or immunosuppressant medications. * HIV infection * Patients with active CNS involvement with malignancy. Patients with prior CNS disease that has been effectively treated will be eligible providing treatment was \>4 weeks before enrollment on the retreatment cohort. * Class III/IV cardiovascular disability according to the New York Heart Association Classification * Patients with a known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the central nervous system.