Peripheral Insulin Uptake in Type 2 Diabetes Mellitus and in Non-Diabetic Individuals

Inclusion criteria for all participants: * written informed consent * hemodynamically stable with a systolic blood pressure \> 100 mmHg * medical need to undergo a CAG procedure as determined by cardiologist Exclusion criteria for all participants: * ongoing myocardial infarction as determined from elevated cardiac markers * participation in an investigational trial within 90 days prior to present study * donation of blood (\> 100 mL) within 90 days prior to present study * serious mental impairment or language problems i.e. preventing to understand the study protocol/aim * Use or recent use (within 3 months of study participation) of oral glucocorticoids Inclusion criteria for non-diabetic individuals: * 30 years ≤ age ≤ 80 years (extremes included) * fasting glucose level of \< 7.0 mmol/L and HbA1C \< 6.5% (= \< 48 mmol/mol) Exclusion criteria for non-diabetic individuals: \- known T2DM/use of glucose-lowering medication Inclusion criteria for T2DM patients: * 30 years ≤ age ≤ 80 years (extremes included) * fasting glucose level of \> 7.0 mmol/L, or HbA1C \> 6.5 (= \> 48 mmol/mol) or known T2DM Exclusion criteria for T2DM patients: \- treatment with insulin preparations