The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to diuretics.
This prospective pilot "pre-post" study was designed to determine if supplementation of sodium free chloride ion as a lysine chloride to patients with heart failure could improve parameters of neurohormonal status and diuretic responsiveness. Volunteers will receive Lysine Chloride 7 grams three times daily for three days. At baseline and then again post lysine chloride patients will undergo sampling of venous blood for determination of neurohormonal parameters in addition to formal diuretic responsiveness testing.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
11
Administration of 21g of lysine chloride (7g three times daily) for a period of time of 3 days
Yale New Haven Hospital
New Haven, Connecticut, United States
Change in plasma renin activity following lysine chloride administration
Time frame: 3 days
Change in urinary renin level following lysine chloride administration
Time frame: 3 days
Change in diuretic response following lysine chloride administration
Diuretic response will me evaluated by measuring volume of urine produced following diuretic administration
Time frame: 3 days
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