Treatment Response to Different Lymphoedema Compression Programs Using a Pneumatic Compression Device

Inclusion Criteria: * Subjects must be ≥ 18 years old * Subjects must have a diagnosis of primary or secondary Stage 2 unilateral or bilateral lower extremity lymphoedema * Must currently be using adequate compression garment(s) as determined by the clinician: (Garments must be at least 20mmHg and no more than 3 months old and must be worn upon rising and removed at bedtime) * Subjects must have clinically relevant excess limb swelling as determined by clinician "pitting test" * Must be able to attend all required in-clinic treatment visits Exclusion Criteria: * Diagnosis of active or recurrent cancer, or less than 3 months at the time of initial evaluation from the completion of chemotherapy, radiation therapy, or primary surgery for the treatment of cancer * Active infection or inflammation * Active thrombophlebitis (within the last 2 months) * History of pulmonary embolism (within the last 2 months) * Documented history of deep chronic venous insufficiency or deep venous obstruction with a reflux duration of \> 2 second in the deep system or any history of deep vein thrombosis (DVT) * History of pulmonary edema * History of congestive heart failure * History of chronic kidney disease with a glomerular filtration rate (GFR) of less than 30 mls per minute * Poorly controlled asthma * Symptomatic or severe peripheral artery disease (defined by current lifestyle-limiting claudication or critical limb ischemia) * Presence of an open wound or ulcer of any etiology * Diagnosis of lipoedema and lipolymphoedema * Currently using an in-home pneumatic compression device * Metal implant(s) that would interfere with bioimpedance equipment * Pacemaker or other implanted electronic device(s) * Unable or unwilling to remove bandaging from treatment regimen while participating in the study * Pregnant * Any condition where increased venous and lymphatic return is undesirable * Unable or unwilling to participate in all aspects of the study protocol and/or unable to provide informed consent * Currently participating in another clinical trial * Currently using diuretics * BMI \> 40