The Desensitization Therapy With GB-0998 for Anti-donor Antibody-positive Recipients.

Inclusion Criteria: * Patients with stage 4 or 5 on the CKD classification. * Of the patients that wants a living-donor kidney transplant of ABO blood type compatible, patients with positive FCXM-T and negative CDC-T to the donor. * Patients with positive FCXM-T after performing twice DFPP therapy Exclusion Criteria: * Patients who had taking to continue immunosuppressive drugs or steroids within 4 weeks before obtaining informed consent. * Patients who had IVIG therapy, or plasmapheresis therapy within 12 weeks before to informed consent. * Patients who had Rituximab within 6 month before to informed consent. * Patients who have undergone splenectomy. * Patients with severe hepatic disorder or severe heart disorder. * Patients with receiving treatment of malignancy. * Patients with high risk of thromboembolism. * Patients with history of shock or hypersensitivity to GB-0998. * Patients with hereditary fructose intolerance or IgA deficiency. * Patients with pregnant or probably pregnant.