Effect of Chlorhexidine on Bacteriuria

Phase 4UnknownNCT02032394

Mashhad University of Medical Sciences105 enrolled

Overview

This study is conducted to determine and compare the effect of applying Povidone-iodine and Chlorhexidine solutions for perinea washing on bacteriuria rate and type in patients with urinary catheter in intensive care unit.

This is a double blind randomized study with control group. The population is patients in intensive care unit of Shahid Beheshti hospital of Babol city. Main include criteria are 18-55 years old, need to having urine catheter for 10 days at least and no urinary infection in catheterization time. Main exclude criteria are appearing genital wound, allergic or dermatitis disorders. Sample size include 105 patients dividing in three equal groups of Povidone-iodine, Chlorhexidine and Normal saline randomly. Interventions are Washing perinea area and catheter first 5 centimeters by 15 ml of Povidone-iodine 10%, Chlorhexidine .2% or Normal saline .9%, 3 times a day for 10 days. Urine analysis are performed in days 1,3,5,7 and 9 after catheterization and urine cultures are performed in days 5 and 10 after catheterization for detection of bacteriuria and microorganism type.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

105

Conditions

Urinary Tract Infection Nosocomial Infection Bacteriuria

Interventions

Povidone-iodineDRUG

15 ml 10%, 3 imes a day for 10 days /external use for Washing perinea area and catheter first 5 centimeters

ChlorhexidineDRUG

15 ml .2%, 3 imes a day for 10 days /external use for Washing perinea area and catheter first 5 centimeters

Normal salineDRUG

15 ml .9%, 3 imes a day for 10 days /external use for Washing perinea area and catheter first 5 centimeters

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Must need a urinary catheter for 10 days at least * Must have 18-55 years old * Men subjects must doing circumcision already * Urinary catheter must be apply in a standard method by researcher or via her supervision Exclusion Criteria: * No more tendency of patient or his/her significant other for continuing study * Malignant disease such as prostate or uterine cancer * History of recurrent urinary infection * Congenital urinary system disorders * history of allergy * Immunodeficiency disorders * Urinary system intervention in past sixth months * Urinary infection at study start * Positive urine analysis or urine culture results in first 3 days of study * Abdominal or pelvic surgery * Women having period during study * Any allergic reaction or dermatitis resulted from applying study solutions * Appearing genital wounds * Diabetes mellitus * Wound in genital area * Discharging, transferring or dying in first week of study

Locations (1)

Shahid Beheshti Hospital

Babol, Mazandaran, Iran

RECRUITING