Safety, Pharmacokinetics and Acceptability of PC-1005 for Vaginal Use

Inclusion Criteria: * Women between 19 and 49 years of age, inclusive * Willing and able to provide written informed consent * Healthy, based on medical history, vital signs, physical examination, urinalysis, laboratory evaluations for genital infections and laboratory evaluations for hematology, liver and renal function with a BMI ≥18 kg/m\^2 and ≤32 kg/m\^2 * HIV-negative as determined by HIV ELISA test at screening * Hepatitis B and C negative at screening * Rapid plasma reagin negative at screening * If HSV-2 positive, must be free from outbreaks for at least 6 months prior to screening * In the absence of the use of exogenous hormone(s), have a self-reported regular menstrual cycle, defined as having a minimum of 21 days and a maximum of 35 days between menses * Normal Pap test at screening * Agrees to use one form of effective contraception for the duration of the trial * Willing to abstain from sexual intercourse/activity including receptive vaginal, oral, digital, and anal intercourse, and the use of any vaginal products including tampons, male and female condoms, contraceptive sponges, diaphragms, cervical caps, douches, lubricants, and vibrators/dildos starting from the Screening Visit through Study Exit * Agrees to not participate in any other clinical research trial for the duration of this trial Exclusion Criteria: * History of or known sensitivity/allergy to any component of either study product * Currently pregnant or breast-feeding, or within 3 months of last pregnancy outcome * Participation in any other clinical research trial involving investigational or marketed products currently or within two months of participation prior to screening, including any trial of a spermicide, microbicide and/or drug * Diagnosed with or treated for any STI (other than HSV) or pelvic inflammatory disease in the last 3 months * Positive test for Neisseria gonorrhea, Chlamydia trachomatis, or Trichomonas vaginalis * Symptomatic vulvovaginal candidiasis, bacterial vaginosis (BV), or urinary tract infection (UTI) at screening * Presence of any clinically significant genital epithelial findings such as abrasions, ulcerations, lacerations, or vesicles suspicious for STIs at screening * Presence of any other clinically significant abnormal physical finding on the vulva, vaginal walls or cervix at screening * Any clinically significant abnormal hematology, chemistry or urinalysis findings at screening * Any chronic (excluding HSV-2) or progressive disease (including any known history of cancer, diabetes, cardiac disease, autoimmune disease, blood dyscrasias, or Wilson's disease), or signs of cardiovascular disease, or renal failure, even controlled with medication * History of hysterectomy or menopause * Use of excluded contraceptive methods including Nuvaring®, condoms (male or female), contraceptive sponge, diaphragm, or cervical cap (Safety Run-in and Main study) * History of gynecological surgery or procedure within past 2 months * History of uterine prolapse, undiagnosed vaginal bleeding or urethral obstruction within the last 3 months, including break-through bleeding requiring sanitary protection * Known current drug abuse, including illicit drugs, or alcohol abuse * Any other condition(s) that, in the opinion of the Investigator, might interfere with adherence to trial requirements or evaluation of the trial objectives * Unable to comply with study requirements, including but not limited to, attending all study visits, using the gel as directed, observing abstinence throughout the study and use of effective contraceptives, limiting alcoholic beverages to 2 per day and caffeine to no more than 6 servings per day * History of latex allergy