Surgical bypassing of a longer section of the small bowel (when doing a gastric bypass operation) gives better results on body weight in the superobese. We do not yet know whether it is beneficial to exclude more of the proximal small bowel or more of the distal. Side effects of bypassing can also be different. Study aims at clarifying possible differences in effects and side-effects of these two surgical-technical variations.
Randomisation in the OR between long biliopancreatic limb and long alimentary limb. GAstric component identical. Perioperative biopsies to assess mucosal properties at the gastrojejunostomy and the enteroanastomosis. Repeat biopsies (gastroscopy) at one year to identify changes in the mucosa at the Gastroenteroanastomosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
200
RYGB with 200 cm BP limb and 150 cm common limb, effect on EWL, QoL and complications
RYGB with 60 cm BP limb and 150 cm alimentary limb, effect on
Aleris Obesity
Lund, Sweden
RECRUITINGBody weight reduction
Body weight reduction is currently the best substitute endpoint to correlate with the hard endpopints such as death, comorbidities etc.
Time frame: 2 years from end of inclusion
Patient assessed quality of life
We employ SF-36, Op-9, GSRS, TFEQ scales
Time frame: 2 years from end of inclusion
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