Phase IV Bioseal Study in Brain Tumor Surgery

Inclusion Criteria: * Subjects between 18 and 75 years of age * Undergoing elective meningioma surgery and having a tumor cavity * Presence of an appropriate Target Bleeding Site (TBS) as identified intra-operatively by the surgeon requiring an adjunct to achieve hemostasis * Able and willing to comply with procedures required by protocol * Signed and dated written informed consent prior to any study related procedures. Exclusion Criteria: * Subjects undergoing emergency surgery * Subjects with any intra-operative findings that may preclude conducting of the study procedures * Intended use of Fibrin Sealants (including autologous Fibrin Sealants) other than Bioseal on the Target Bleeding Site (TBS) * Subjects with known intolerance to blood products or to one of the components of the study product or unwilling to receive blood products * Subjects who have a history of traumatic head injury * Female subjects who are known breastfeeding or pregnant or intend to become pregnant during the clinical study period * The subject, in the opinion of the investigator, would not be suitable for participation in the study * Subjects who participated in another trial within 30 days prior to the planned start of treatment.