Data of survival benefit from adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) for locally advanced cervical cancer (LACC) are still limited and inconsistent. We will investigate if ACT has survival benefit over CCRT alone.
Concurrent chemoradiation (CCRT) is the standard treatment for cervical cancer of FIGO stage IIB-IVA or so called locally advanced cervical cancer (LACC). However, failure rate after treatment is still as high as 30% to 40%. This is a multi-center randomized controlled trial which evaluates whether adjuvant chemotherapy (ACT) after CCRT will improve treatment outcome comparing to CCRT alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
500
Radiation: * Pelvic radiation 1.8 Gy/ day, 5 days/ week, 6 weeks * Brachytherapy 30-35 Gy for 4-5 times
Cisplatin 40 mg/m2 i.v.
Paclitaxel 175 mg m2 i.v.
Bhumibol Adulyadej Hospital
Bangkok, Bangkok, Thailand
RECRUITINGDepartment of Obstetrics and Gynecology, Department of Radiology, Epidemiology Unit, Navamindradhiraj University
Bangkok, Bangkok, Thailand
Progression-free survival
3-year progression free survival
Time frame: 3 years
Overall survival
3-year overall survival
Time frame: 3 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Carboplatin AUC 5 i.v.
Health Intervention and Technology Assessment Program
Bangkok, Bangkok, Thailand
NOT_YET_RECRUITINGChonburi Cancer Hospital
Chon Buri, Changwat Chon Buri, Thailand
RECRUITINGLampang Cancer Hospital
Lampang, Changwat Lampang, Thailand
RECRUITINGLopburi Cancer Hospital
Lopburi, Changwat Lop Buri, Thailand
RECRUITINGRatchaburi Hospital
Muang, Changwat Ratchaburi, Thailand
ACTIVE_NOT_RECRUITINGDepartment of Obstetrics and Gynecology, Department of Radiology, Prince of Songkla University
Songkhla, Changwat Songkhla, Thailand
RECRUITINGDepartment of Radiology, Department of Obstetrics and Gynecology, Chiang Mai University
Chiang Mai, Chiang Mai, Thailand
RECRUITINGUbonratchathani Cancer Hospital
Ubonratchathani, Ubonratchathani, Thailand
RECRUITING...and 1 more locations