The purpose of this study is to determine whether 0.5% ivermectin cream is effective in the treatment of demodicidosis (including papulopustular rosacea)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
50
Each participant will be treated with topical ivermectin cream 0.5% qd for one half of the face and with a vehicle cream qd for the other half of the face for 1 month. In the second month all patients will be treated with ivermectin cream for the entire skin involvement.
RabinMC, Dermatology dept.
Petah Tikva, Israel
RECRUITINGA decrease in mite density in skin surface biopsy after treatment with topical ivermectin (≤5 mites/cm2 for skin lesions).
Time frame: 5 months
Clinical improvement
Clinical improvement will be assessed by objective evaluation of erythema, dryness, scaling, roughness, and/or papules/pustules in skin lesions and subjective evaluation of itch and dryness.
Time frame: 5 months
A comparable dermoscopic improvement in the demodicidosis features
dermoscopic demodicidosis features: * number of demodex tails * demodex follicular openings * reticular dilated vessels.
Time frame: 5 months
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