Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer

Inclusion Criteria: 1. Age ≥ 18 years 2. ECOG performance status 0 or 1 3. Life expectancy of ≥ 6 months 4. Minimally-symptomatic or asymptomatic, castrate-resistant metastatic prostate cancer, as evidenced by all of the following: 1. Histologically-confirmed diagnosis of adenocarcinoma of the prostate 2. Evidence of adequate androgen deprivation, as evidence by one of the following: * Bilateral orchiectomy * Ongoing LHRH agonist (e.g. leuprolide, goserelin) and serum testosterone \<50 ng/dl * Ongoing LHRH antagonist (e.g. degarelix) and serum testosterone \<50 ng/dl 3. Evidence of prostate cancer resistance to castration, as evidenced by one of the following: * 2 consecutive PSA levels that are ≥ 50% above the PSA nadir achieved on ADT and obtained at least 1 week apart * CT or MRI based evidence of disease progression (soft tissue or nodal) according to PCWG2 criteria or RECIST 1.1 criteria, or at least 1 new bone scan lesion as compared to the most immediate prior radiologic studies. 4. Presence of non-visceral metastases on imaging 5. Absence of major symptoms directly attributable to prostate cancer, with the following permissible exceptions: * Ureteral obstruction secondary to pelvic or retroperitoneal lymphadenopathy * Bladder outlet obstruction secondary to locally recurrent prostate cancer 5. Radiographic evidence of lymphadenopathy, defined as a lymph node greater than 1 cm in diameter on axial imaging (CT or MRI or PET/CT) 6. Adequate laboratory parameters 7. A minimum of 4 weeks from any major surgery prior to registration. Coincident standard of care surgery with the research biopsy is permitted during the study. Exclusion Criteria: 1. Prior treatment with sipuleucel-T 2. Allergy to any component of sipuleucel-T 3. Inability to undergo leukapheresis 4. History of neuroendocrine variants of prostate cancer, including small cell carcinoma of the prostate 5. Extensive prior surgery/radiation present that would render the biopsy highly complex and the risk of intraoperative injury high 6. Any chronic medical condition requiring daily corticosteroids or other immunosuppressants 7. Solid organ transplantation requiring immunosuppression 8. Visceral (e.g. lung, liver) metastases 9. Known brain metastases 10. History of spinal cord compression 11. Untreated/unstabilized pathologic long bone fractures 12. Other malignancy, except non-melanoma skin cancer, with a ≥ 30% probability of recurrence within 24 months 13. Administration of any investigational therapeutic within 30 days of registration 14. Any condition which, in the opinion of the investigator, would preclude participation in this trial