A Phase 1, Open Label, Ascending Dose Cohort Study of the Pharmacokinetics of Anti-Influenza Hyperimmune Intravenous Immunoglobulin in Healthy Subjects

* INCLUSION CRITERIA: 1. Age greater than or equal to 18 years and less than or equal to 50 years 2. Weight less than or equal to 100 kg 3. Patients must be willing to forgo the seasonal influenza vaccine for 28 days, and the MMR and varicella vaccines for 3 months post infusion of the study drug 4. Females who are able to become pregnant (i.e., are not postmenopausal, have not undergone surgical sterilization, and are sexually active with men) must agree to use at least 1 effective form of contraception from the date of the subject s signing of the informed consent form through 28 days after the dose of the study drug EXCLUSION CRIATERIA: 1. Any chronic medical problem that requires daily oral medications (except Tylenol, oral contraceptives, vitamins, and seasonal allergy medications), or other medical history that in the opinion of the investigator significantly increases the risk associated with IVIG 2. Women who are breast-feeding 3. Positive urine or serum pregnancy test 4. Known sensitivity to IVIG 5. IgA \< 7 mg/dL 6. Influenza HAI H1N1 \> 1:20 7. Receipt of any vaccination within 30 days prior to study drug administration 8. Pre-existing condition that is associated with an increased risk of thrombosis such as cryoglobulinemia, hyper-triglyceridemia, or monoclonal gammopathies 9. Estimated glomerular filtration rate (GFR) \< 60 mL/min at screening, calculated using the MDRD formula 10. Medical conditions for which receipt of up to 750 mL volume may be dangerous to the patient (e.g., decompensated congestive heart failure) 11. Abnormal chemistry panel -Defined as any clinically significant baseline Grade 1 or greater toxicity, or any Grade 3 or greater toxicity (regardless of clinical significance) by the toxicity table --Evaluating only total CO2 (bicarbonate), creatinine, alkaline phosphatase, ALT, AST, total bilirubin, and estimated GFR by the MDRD equation 12. Abnormal complete blood count (CBC) -Defined as any clinically significant baseline Grade 1 or greater toxicity, or any Grade 3 or greater toxicity (regardless of clinical significance) by the toxicity table --Evaluating only the WBC, hemoglobin, hematocrit, and platelets 13. Positive serology for Hepatitis B surface antigen 14. Positive serology for Hepatitis C 15. Positive serology for HIV-1 16. Prior treatment with any investigational drug therapy within 5 half-lives or 30 days, whichever is longer, prior to study drug administration (i.e., Day 0) 17. Receipt of blood products from 30 days prior to study drug administration (i.e., Day 0) through 28 days after the dose of the study drug 18. Presence of any pre-existing illness that, in the opinion of the investigator, would place the patient at an unreasonably increased risk through participation in this study 19. Patients who, in the judgment of the investigator, will be unlikely to comply with the requirements of this protocol.