Impact of Ticagrelor on the Endothelial Healing Following Drug-eluting Stent Implantation in the Patients With Acute Coronary Syndrome

Phase 4TerminatedNCT02037412

Yonsei University148 enrolled

Overview

The investigators hypothesized that ticagrelor may enhance endothelial healing after DES implantation by increasing adenosine concentrations by the inhibition of adenosine uptake into erythrocytes, compared to clopidogrel. Thus, the investigators will evaluate the extent of endothelialization (stent strut coverage) and neointimal hyperplasia (neointimal thickness) 3 months after DES implantation by optical coherence tomography (OCT)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

148

Conditions

Acute Coronary Syndrome Acute Myocardial Infarction Unstable Angina (Intermediate Coronary Syndrome)

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients ≥ 20 years old * Patients who are hospitalized and expected to undergo PCI for acute coronary syndrome, including acute myocardial infarction and unstable angina. Exclusion Criteria: * Age \> 80 years * Cardiogenic shock or unstable patients * Increased risk of bleeding, anemia, thrombocytopenia * A need for oral anticoagulation therapy * Pregnant women or women with potential childbearing * Life expectancy \< 1 year

Outcomes

Primary Outcomes

Stent re-endothelialization

Percentage of stent coverage measured by OCT

Time frame: Three months after stent implantation

Neointimal hyperplasia

Neointimal thickness measured by OCT