Ultrasonographic Measurements of the Median Nerve Before and After Splinting for Carpal Tunnel Syndrome

Inclusion Criteria: * 18 years or older and; * Diagnosis of mild to moderate CTS with median motor latency at 8 cm is greater than 4.5 milliseconds or Combined Sensory Index \> 0.9 where first line therapy is indicated to include nocturnal wrist bracing * Control subjects without symptoms of carpal tunnel syndrome. Exclusion Criteria: * Evidence of severe CTS as seen with electromyographic changes in the body of the muscle * Untreated hypothyroidism, Rheumatologic disorders * Diagnosed Severe CTS or Chronic symptoms of carpal tunnel, greater than 1 year, this includes wasting of the hand muscles * Undergoing or previously treated for carpal tunnel on affected side. This includes surgery (carpal tunnel release), corticosteroid injections, bracing within the last 3 months while wearing the brace consistently every night, or any other intervention. * Currently pregnant or \< 3 months post partum * History of wrist, hand fracture or severe trauma to affected hand and/or wrist * Known tumor, mass or deformity of the hand/wrist * Inflammatory articular disease of the joints or tendons Existing cervical radiculopathy or previous surgeries to the neck for radicular symptoms * History of electrodiagnostic evidence of generalized polyneuropathy or evidence of denervation * Diagnosed neuromuscular disorders which may complicate CTS diagnosis * Implanted electronic device (pacemaker, intrathecal pump/stimulator) * Any illness that makes it unsafe for the patient to participate in the study * Not fluent in English as NeuroQOL and other subjective information is limited to the English language interpretation