MIDNOR-TIA - a Study of 600 Patients With Transient Ischemic Attack

N/ACompletedNCT02038725

Norwegian University of Science and Technology584 enrolled

Overview

Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low and high risk for stroke. The main purpose of this study is to investigate stroke risk after TIA in both short (1 week) and long term (3 months/1 year), and to assess whether the ABCD2 score ('Age, blood pressure, clinical features, duration of TIA, diabetes score) is an adequate tool for predicting stroke risk. Secondary aims are to explore whether adopting imaging modalities (ultrasound, MRI) and biological markers of blood into a risk score could improve the predictive value of the ABCD2 score and still be feasible in a daily clinical practice. Further on overall risk factors in TIA patients, and the incidence of other vascular events will be studied. A substudy designed as a randomised controlled trial evaluates pharmaceutical counseling in a subset of participants. Cost-benefit analysis, and a long-term follow-up (5 years) is planned.

Study Type

OBSERVATIONAL

Enrollment

584

Conditions

Ischemic Attack, Transient Stroke

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Probable or possible transient ischemic attack * Residing in Central Norway * Examined within 2 weeks after the onset of symptoms * Modified Rankin Scale 3 or less and living at home * Informed consent

Locations (8)

Ålesund Sykehus

Ålesund, Norway

Kristiansund Sykehus

Kristiansund, Norway

Levanger Sykehus

Levanger, Norway

Molde Sykehus

Molde, Norway

Namsos Sykehus

Namsos, Norway

Orkdal Sykehus

Orkanger, Norway

St Olavs Hospital

Trondheim, Norway

Volda Sykehus

Volda, Norway

Outcomes

Primary Outcomes

Number of patients presenting with stroke within 1 week after transient ischemic attack

Measured by using data from the Norwegian Stroke Registry

Time frame: 1 week

Secondary Outcomes

Number of patients presenting with stroke within 3 months after transient ischemic attack

Measured by using data from the Norwegian Stroke Registry

Time frame: 3 months

Correlation between the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack

Measured by comparing the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack based on data from the Norwegian Stroke Registry

Time frame: 1 week

Correlation between the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack

Measured by comparing the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack based on data from the Norwegian Stroke Registry

Time frame: 3 months

Incidence of other vascular events within 1 week after transient ischemic attack

Measured by using data from national health registries

Time frame: 1 week

Cost-benefit analysis

Economic analysis that compares the costs of admission to hospital versus outpatient assessment of patients who have had transient ischemic attacks

Time frame: 1 year

Number of patients presenting with stroke within 1 year after transient ischemic attack

Measured by using data from the Norwegian Stroke Registry

Time frame: 1 year

Correlation between the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack

Measured by comparing the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack based on data from the Norwegian Stroke Registry

Time frame: 1 year

Incidence of other vascular events within 3 months after transient ischemic attack

Measured by using data from national health registries

Time frame: 3 months

Incidence of other vascular events within 1 year after transient ischemic attack

Measured by using data from national health registries

Time frame: 1 year