Reduction in Symptomatic Esophageal Stricture Formation

Inclusion Criteria: 1. Histologically confirmed Barretts mucosa with high grade dysplasia or early esophageal adenocarcinoma (T1a, intramucosal adenocarcinoma). 2. Barretts segment ≥ 30% circumference, ≤C3 and ≤M5. 3. The general health condition of the patient permits anesthesia for endoscopy. 4. Patient is 18 years of age or older. 5. Informed consent is obtained Exclusion Criteria: 1. Previous (referral) biopsies show low grade dysplasia only, or invasive adenocarcinoma. 2. Barretts segment \<30% circumference, \>C3 or \>M5. 3. During initial gastroscopy there are highly suspicious areas for submucosal invasive cancer (Kudo pit pattern type V; excavated/depressed type morphology; large smooth or ulcerated nodule). In cases of significant doubt, initial resection is of the highly suspicious area only, and urgent histology processing requested. If submucosal invasion is excluded, the patient is rebooked for 1st stage complete barrett's excision (60% circumferential resection) and randomization after a 4-6 weeks interval. 4. Presence of a tight peptic oesophageal stricture that impedes safe and effective endoscopic mucosal resection using a cap (Cook Medical). 5. Active malignancy, uncontrolled Diabetes Mellitus, active or untreated major psychiatric disorder, uncontrolled infection, uncontrolled hypertension, uncontrolled or severe congestive cardiac failure, non-correctable coagulopathy (INR\>2, or platelet count \<60 x 109/L), osteoporosis, recent peptic ulcer disease, moderate-to-severe glaucoma or untreated glaucoma, or pregnancy. 6. Unable to provide informed consent 7. Allergy to compound used in tablet formulation