Study of Nimotuzumab in Combination With Neoadjuvant Chemotherapy for Cervical Cancer

Inclusion Criteria: 1. Age:18-70 years 2. Histological confirmed Cervical squamous cell carcinoma 3. FIGO Stage: IB2-IIIB 4. Tumor lesions and stages are confirmed by the internal medicine, obstetrics and gynecology inspection, including a pelvic exam and abdominal and pelvic CT,.if necessary, laparoscopy, cystoscopy and pelvic MRI examination will be taken. 5. At least one lesions can be measured 6. No previous therapy 7. ECOG performance status 0-2 8. Life expectancy of more than 6 months 9. Normal hematology:Haemoglobin≥90g/L,white blood cell(WBC)≥4×109/L Absolute neutrophil count≥1.5×109/L,platelet count≥100×109/L, normal renal function: serum creatinine\<1.5mg/dl or creatinine clearance rate\>60ml/min；normal liver function:TBIL≤1.5 ULN, AST and ALT≤1.5 ULN 10. Without lung or heart disease 11. Without active infection 12. Signed informed consent and submit to the organization of research Exclusion Criteria: 1. Severe systemic or uncontrolled disease, unfit for chemotherapy 2. Neuropathy caused by any reason 3. Psychiatric disease 4. Other malignant tumor 5. Bilateral renal pelvis and ureter hydrocephalus who can't be alleviated by ureteral stent or percutaneous nephrostomy, Abnormal serum creatinine level 6. Infection and severe systemic disease 7. Received other anti EGFR monoclonal antibody treatment 8. Participation in other interventional clinical trials 9. Allergic constitution or history of drug allergy 10. Pregnant or breast-feeding or refused to take contraceptive method 11. Poor compliance