A small gastric remnant after whipple resection improves gastric emptying and therefore prevents the development of delayed gastric emptying.
Every patient submitted to a whipple resection and at the same time present with characteristics suggestive of minimal risk for leakage from the pancreaticojejunostomy will be included in the study. At the time of reconstruction the patient will be randomized to either conventional size of the stomach or to a subtotal gastrectomy containing a small upper gastric pouch only.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
7
Subtotal gastrectomy as an adjunct to traditional whipple procedure.
All patients undergoing whipple procedure without risk for pancreaticojejunal anastomosis leakage.
Karolinska University Hospital Gastrocentrum
Stockholm, Sweden
Postoperative delayed gastric emptying
During the postoperative phase the patient will be followed daily with assessment of symptoms suggestive of delayed gastric emptying.
Time frame: Postoperative recovery period in days (on an average <20 days)
Quality of life
Quality of life measured by use of scientifically validated instruments.
Time frame: during three first postoperative months
Postoperative hospital stay
Time in days from the operation to discharge from hospital.
Time frame: In hospital stay in days (on an average <20 days)
Total Gastric emptying as measured by the paracetamol test
Paracetamol orally ingested together with chocolate biscuits whereafter peripheral venous blood concentrations of paracetamol are determined. Blood samples taken at baseline and every 15 minutes after paracetamol ingestion during the first hour and then every 30 minutes for an hour.
Time frame: three months postoperatively
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