The Effect of Different Doses of Remifentanil on Kidney Function During Robot Assisted Prostatectomy - A Retrospective Study

N/AUnknownNCT02041559

Yonsei University1,500 enrolled

Overview

Robot assisted prostatectomy reduces the patients' postoperative pain and leads to rapid rehabilitation. But pneumoperitoneum affects the kidney. The increase of stress hormone reduces the glomerular filtration and the vaso-contraction of renal vessels leads the renal ischemia. Remifentanil is analgesics coupled with μ opioid receptor. In high dose of remifentanil, it is associated with κ and δ receptors, which leads to renal protection effect in animal study. Also, remifentanil infusion during anesthesia showed a diuretic effect. The purpose of this study is to investigate the remifentanil effect on renal function during robot assisted prostatectomy.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Prostate Cancer

Eligibility

Sex: MALEMin age: 20 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ages \> 19 years and \< 85 years * the patients undergoing a general anesthesia for robot assisted prostatectomy Exclusion Criteria: * incomplete record * history of opioid or steroid using * solitary kidney * history of kidney transplantation

Locations (1)

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health System

Seoul, South Korea

Outcomes

Primary Outcomes

acute kidney injury incidence based on Acute Kidney Injury Network criteria

Acute kidney injury incidence based on Acute Kidney Injury Network criteria was defined as increase in serum creatinine from baseline of ≥ 0.3 mg/dl within a 48-hour period. Acute kidney injury is evaluated at POD 1.

Time frame: 24 hours after end of surgery