Unknown Cause of Acute Liver Failure

N/ACompletedNCT02041637

Assistance Publique - Hôpitaux de Paris72 enrolled

Overview

The purpose of the study is to evaluate the outcome and to determine predictive factors of patients admitted in a context of acute liver failure without identified cause.

Methodology: Multicentric French national cohort with prospective collection of data and constitution of biobank, in patients hospitalized in a context of acute liver failure without known cause at admission. Follow-up during 3 months for each patients. The primary objective is to determine predictive factors of early mortality. This study is an observational cohort and patients will received standard care during the follow-up.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Failure Unknown Etiology

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute liver failure defined by a PT\<50% or INR\>1.5; * with or without hepatic encephalopathy; * without cause identified at admission, and non A non B hepatitis; * age\>18 year old; * signed an informed consent. Exclusion Criteria: * chronic liver disease; * Patient under guardianship

Locations (1)

AP-HP, Paul Brousse Hospital, Centre Hepato-Biliaire

Villejuif, France

Outcomes

Primary Outcomes

mortality

Time frame: At 3 months

Secondary Outcomes

Liver transplantation rate

Time frame: At 3 months

Overall survival rate

Time frame: At 3 months

post-transplant mortality rate

Time frame: At 3 months

Data from ClinicalTrials.gov

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