Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count responsible for bleedings. The disease is mostly mediated by antiplatelet antibodies produced by specific B cells. However, T cells are also involved but their role is not completely understood. The aim of this study is to determine the implication of T cells in the pathogenesis of ITP, notably regulatory T cells (Treg, CD4+CD25highFoxp3+), cytotoxic T cells (CD3+CD8+) and T follicular helper cells (TFH, CD3+CD4+CXCR5+PD-1+ICOS+), in blood and in the spleen of primary ITP patients, compared to healthy controls.
Study Type
OBSERVATIONAL
Enrollment
89
CHU de Besançon
Besançon, France
CHU de Dijon
Dijon, France
CHU de METZ
Metz, France
blood level T cell in ITP patients and in healthy controls
Time frame: baseline
blood level T cell in ITP patients after treatments
Time frame: change from baseline at 4 to 8 weeks
blood level splenic T cell in ITP patients and in healthy controls
Time frame: baseline
frequency of innate immune cells (dendritic cells, monocytes, NK cells…) and their functions in blood and spleens, in patients and in controls
Time frame: through study completion, an average of 3 years
level of T follicular helper cell
Time frame: through study completion, an average of 3 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.