Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression

Inclusion Criteria: Depressive patients to be treated with rTMS or SSRI: * who have provided written informed consent * who are covered by the national health insurance scheme * who suffer from characterized depression (DSM-IV criteria) that is considered severe (Hamilton-17 item scale ≥ 19) * who are aged 18-65 years, * male or female * who have presented at least one failed treatment with medical antidepressants prescribed at an effective dosage for a duration of at least 6 weeks. Controls: * Patients who have provided written informed consent * who are covered by the national health insurance scheme * aged between 18 and 65 years * and either male or female Exclusion Criteria: Depressive patients destined to benefit from treatment with rTMS or SSRI: * Type I or II bipolar disorders * Depression with characteristics of psychosis * Schizophrenia * Abuse of alcohol and/or illegal psycho-active substances. * Dependence on alcohol and/or an illegal psycho-active substance. * Patients unable to provide consent to the protocol because of their mental disorders cannot be included in this study: patients with enforced psychiatric care (SDT, SDRE) or under ward of court. * Contra-indication for rTMS; personal history of convulsions, pacemaker, neurosurgical clips, carotid or aortic clips, cardiac valves, audition prostheses, ventricular derivation valve, sutures with metallic thread or staples, foreign bodies in the eye, shrapnel, protheses or cephalic ferromagnetic implants, metal workers. * Contra-indication for cerebral MRI * Resistance to escitalopram or sertraline (prescription of escitalopram at 20 mg/d or sertraline at 50 mg/d for at least 6 weeks for the last episode) * Contra-indication * for escitalopram : Hypersensitivity to escitalopram or one of the excipients. non-selective and irreversible monoamine oxidase (IMAO) inhibitors, because of the risk of serotoninergic syndrome with agitation, trembling, hyperthermia. reversible MAO-A inhibitors (e.g.: moclobemide) or a non-selective reversible MAO inhibitor (linezolid), given the risk of a serotoninergic syndrome * and to sertraline: Hypersensitivity to one of the components, Hypersensitivity to soja, Hypersensitivity to arachides, Treatment with IMAO * Current pregnancy or breast-feeding: an assay for urinary beta-HCG will be done before inclusion in the protocol for women of child-bearing age. * Contra-indication for escitalopram: * Hypersensitivity to escitalopram or to one of the excipients. No-selective, irreversible monoamine oxidase (IMAO), because of the risk of serotoninergic syndrome with agitation, trembling and hyperthermia. * Reversible MAO-A inhibitors (e.g.: moclobemide) or non-selective reversible MAO inhibitors (linezolid), because of the risk of serotoninergic syndrome. * Patients presenting an acquired or congenital prolonged QT interval and patients on treatments known to prolong or suspected of prolonging the QT interval (list of treatments on azcert.org). * Contra-indication to sertraline: * Hypersensitivity to one of the components, Hypersensitivity to soja, Hypersensitivity to arachides, Treatment with IMAO. Patients treated with pimozide. Controls: * Any current psychiatric disease or a history of psychiatric disease (defined by DSM-IV-TR criteria) * Current addiction (except for occasional smoking) or a history of addiction (defined by DSM-IV-TR criteria) * Any progressive somatic disease (cardiac, hepatic, renal, pulmonary…) * Any pharmacological treatment with the exception of combined oral contraceptive pills * Current pregnancy or breast-feeding: urinary beta-HCG will be assayed before inclusion in the protocol in women of child-bearing age. * Personnel employed in the psychiatry and addictology department of Dijon CHU