This is a pilot sub-study of patients receiving myeloablative transplant using total body irradiation (TBI) or total marrow irradiation (TMI) in their preparative regimen. The objective of this stub-study is to estimate the heterogeneity in cellular proliferation (FLT-PET uptake) as well the heterogeneity in marrow composition distribution (measured using whole body water-fat MRI) using positron emission tomography imaging. This will be used to design future trials as well as to determine the feasibility of PET and MRI imaging.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
2
Functional marrow imaging using the FLT PET/CT will be performed prior to preparative for HSCT and approximately 3 months post-transplant (Day 100 +/- 5 days).
MRI imaging will be performed prior to preparative for HSCT and approximately 3 months post-transplant (Day 100 +/- 5 days).
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, United States
Difference in Percentage of Proliferating Bone Marrow Between Baseline and 100 Days
The difference in percentage of proliferating bone marrow will be calculated for the following sites: skull, proximal humeri, ribs, clavicles, cervical spine, thoracic spine, lumbar spine, sacrum, pelvis and proximal femur.
Time frame: 100 days
Difference in Water Fat
The difference in the water-fat MRI between baseline and day 100 post transplant in L4 and femoral neck.
Time frame: 100 days
Percentage of Proliferating Bone Marrow in the Femur
The difference in the percentage of proliferating bone marrow between baseline and day 100 post transplant in the femur
Time frame: 100 days
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