Identification of Biomarkers for Obstructive Sleep Apnoea Syndrome

N/ACompletedNCT02043483

Universidade Nova de Lisboa120 enrolled

Overview

Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus). Until now, no molecular markers for this physiopathological connection have been identified. This project aims to determine non-invasive biomarkers that may allow better comprehension of the metabolic consequences of OSAS, as well as assess the effect of Continuous positive airway pressure (CPAP) on these metabolic parameters. This project will integrate the clinical, metabolic, genetic/proteomic and biologic systems to further explore the mechanisms behind OSAS, as well as the effect of the treatment with CPAP.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Obstructive Sleep Apnoea Syndrome

Eligibility

Sex: MALEMin age: 25 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male * 25-60 years * Mild/Moderate/Severe OSAS Exclusion Criteria: * Female * Other sleep disorders * Previous CPAP therapy * Type 1 diabetes mellitus * Familiar Dyslipidemia * Severe organ pathology * Acute disease

Locations (1)

Centro Hospitalar Lisboa Norte

Lisbon, Portugal

Outcomes

Primary Outcomes

Percentage of patients with clinical improvement

Treatment efficacy of CPAP will be assessed at the end of treatment through a clinical observation.

Time frame: 6 months

Secondary Outcomes

Frequency of occurence of biomarkers

Using Mass Spectrometric Immunoassay, we will identify which biomarkers have a positive association with long-term treatment effect.

Time frame: 6 months