A Study to Evaluate the Effect of Lorcaserin Hydrochloride on Smoking Cessation

Inclusion Criteria: 1. Males or females aged 18-65 years, inclusive 2. ≥10 cigarettes per day with no period of abstinence longer than 3 months in the past year and who are motivated to quit smoking 3. Able to give signed informed consent 4. Eligible female patients will be: 1. non-pregnant 2. non-lactating 3. agree to use an acceptable method of effective contraception during the study 5. Eligible male patients agree to use contraception when sexually active with a female partner who is not using an acceptable method of birth control 6. Body weight of ≥50 kg (110 pounds), inclusive 7. Considered to be in stable health in the opinion of the investigator Exclusion Criteria: Patients who meet any of the following criteria will be excluded from the study. 1. Prior or current use of lorcaserin HCl 2. Prior participation in any study of a nicotine vaccination 3. Use of other therapies for smoking cessation is not allowed within 3 months of screening through study exit 4. Use of tobacco products other than cigarettes 5. Prior use of fenfluramine or dexfenfluramine 6. Serious or unstable medical condition or clinically significant new illness within the 6 months prior to screening 7. Previous participation in any clinical study within 6 weeks prior to the screening visit 8. History of severe allergies, severe drug or excipient allergy or hypersensitivity 9. History of significant cardiovascular condition 10. History of other significant medical conditions 11. Significant risk of suicide 12. Anticipated use of any agents that are associated with valvulopathy and/or pulmonary hypertension 13. Positive test result for human immunodeficiency virus (HIV), hepatitis B, or hepatitis C 14. Recent history of alcohol or drug/solvent abuse 15. Concurrent participation in the study by more than one member of the same household 16. Not suitable to participate in the study in the opinion of the investigator