The primary purpose of the protocol is to evaluate the efficacy of a protocol for induction of tolerance to peanut ingestion increasing doses. The secondary purpose is to determine the interest of a prolonged maintenance therapy
Prospective randomized double blind, placebo controlled, protocol in two phases: 1/ active treatment versus placebo for induction phase; 2/ long versus short maintenance
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
CHU Clermont-Ferrand
Clermont-Ferrand, France
Percentage of patients which tolerate the cumulative dose of 2 grams of peanut at the end of the first phase of 24 weeks between treatment and placebo groups
Time frame: at 24 weeks
Percentage of patients had quadrupled their tolerance to peanut at the end of induction phase
Time frame: at 24 weeks
Percentage of patients with adverse effects during induction phase
Time frame: at 24 weeks
Modifications of the immune profile showing a desensitization to peanut
Time frame: at 24 weeks
Percentage of patients which tolerate the cumulative dose of 2 grams of peanut during a Double-Blind, Placebo-Controlled Food Challenges (DBPCFCs) after 24 weeks without traces eviction diet after the end of maintenance phase
Time frame: at 24 weeks
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