LifeSeal™ Pilot Study in Subjects Undergoing Circular Stapled Anastomosis Created Within 10 cm of the Anal Verge

Inclusion Criteria: 1. Subject, or authorized representative, signed a written Informed Consent Form 2. Subject is 18 years or older 3. Subject is scheduled for elective open or laparoscopic surgery involving the creation of a circular stapled anastomosis created within 10cm from the anal verge. 4. If female - not be of child bearing potential, or be using acceptable contraception methods. 5. Subject participating in studies involving approved drug or device will be enrolled only following a mutual consideration of the investigator together with the Sponsor. Exclusion Criteria: 1. Subject has a history of hypersensitivity to porcine derived gelatin or collagen 2. Subject participating in any other study involving an investigational (unapproved) drug or device. 3. Subject with a BMI higher than 40 4. Female Subject states that she is pregnant or breast feeding 5. Subject with ASA status higher than 3 6. Avastin use within 30 days prior to surgery 7. Subject who underwent a prior pelvic anastomosis 8. Subject is scheduled for another surgery during the follow up period of this study (not including stoma closure)