To Evaluate Pharmacokinetics of LFF269 in Healthy Volunteers and Patients With Hypertension

Inclusion Criteria: Part 1 \- Healthy men and women of non-childbearing potential, 18 to 80 years of age inclusive, and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening. Part 2 * Hypertensive men and women of non-childbearing potential, 18 to 80 years of age inclusive. * Patients with mild-to-moderate uncomplicated essential hypertension Exclusion Criteria: Part 1 * History of hypersensitivity or allergy to any of the study drugs or to drugs of similar chemical classes. * A history of clinically significant ECG abnormalities. * Known history or current clinically significant arrhythmias. * History of hypertension, adrenal or endocrine disease. * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test. * Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant. * Smokers (use of tobacco products in the previous 3 months). * History of immunodeficiency diseases, including a positive HIV (ELISA and Western blot) test result. * A positive Hepatitis B surface antigen or Hepatitis C test result. Part 2 * Pregnant or nursing (lactating) women. * Women of child-bearing potential. * Known history or evidence of a secondary form of hypertension * Type 1 or type 2 diabetes mellitus. * History of heart diseases * A positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result. * History of immunodeficiency diseases, including a positive HIV (ELISA and Western blot) test result. Other protocol defined inclusion/exclusion criteria may apply