Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures

Phase 4CompletedNCT02048891

Rambam Health Care Campus3 enrolled

Overview

Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given. The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

GnRH agonist trigger

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 44 Years

Medical Language ↔ Plain English

Inclusion Criteria: * IVF patients with at least 4 consecutive failures. * On trigger day, no more than 10 follicles of 12 mm and up Exclusion Criteria: * History of moderate or severe OHSS.

Locations (1)

IVF Unit, Rambam medical Center

Haifa, Israel, Israel

Outcomes

Primary Outcomes

Fetal Heart Activity 1 Month After Oocyte Retrieval

Fetal heart activity as seen by vaginal ultrsound imaging 1 month after oocyte retrieval

Time frame: 1 month after oocyte retrieval

Secondary Outcomes

Patients Comfort During the Luteal Phase

Time frame: During 2 weeks from day of oocyte retrieval

Data from ClinicalTrials.gov

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