Study of Everolimus in Patients With Thymoma and Thymic Carcinoma Previously Treated With Chemotherapy

Inclusion Criteria: * Histological diagnosis of invasive recurrent or metastatic thymoma or thymic carcinoma confirmed by pathologist. * At least one prior platinum-containing chemotherapy regimen. There is no limit to the number of prior chemotherapy regimens received. Progressive disease should have been documented before entry into the study. * Measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as greater than 20 mm with conventional techniques or as greater than 10 mm with spiral CT scan. * Patients must have recovered from toxicity related to prior therapy to at least to grade 1 (defined by CTCAE 3.0). * No major surgery, radiation therapy, chemotherapy, biologic therapy (including any investigational agents), or hormonal therapy (other than replacement), within 4 weeks prior to entering the study. * Life expectancy of at least 3 months. * Performance status (ECOG)\<=2 * Negative pregnancy test (if female in reproductive years) * Adequate organ and marrow function (as defined below) * Leukocytes \>=3,000/mm, Absolute neutrophil count \>=1,500/mm, Hemoglobin\>= 9 g/dL, Platelets\>= 100,000/mm, Total bilirubin \>= 1.5 x institutional upper limit of normal (ULN), AST(SGOT)/ALT(SGPT)\>= 3 x institutional ULN (5x if LFT elevations due to liver metastases, )Creatinine \<= 1.5 x institutional ULN Exclusion Criteria: * Patients with symptomatic brain metastases. However, patients who have had treatment for their brain metastases and whose brain metastatic disease status has remained stable for at least 3 months without steroids may be enrolled at the discretion of the investigator. * Major surgery, other than diagnostic surgery, within 4 weeks prior to treatment * Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy * Pregnant or breast feeding women * Previous (within the last 5 years) or current malignancies at other sites, except for adequately treated basal cell or squamous cell skin cancer or in situ carcinoma of the cervix uteri * Current enrollment in or participation in another therapeutic clinical trial within 4 weeks preceding treatment start. * Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgement of the Investigator, would make the patient inappropriate for entry into this study or could compromise protocol objectives in the opinion of the Investigator and/or the Sponsor.