The objective of this study is to assess the feasibility of estimating the clearance of iohexol as an indirect measure of glomerular filtration rate in patients with unstable renal function in the intensive care unit through analysis of rich iohexol plasma kinetics.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
100
Iohexol, 300 mg/mL
Hospital La SOURCE
Orléans, France
University Hospital Strasbourg
Strasbourg, France
Service de Réanimation Polyvalente, CHRU de Tours
Tours, France
Plasma clearance of iohexol
Time frame: 24 hours
Plasma clearance of iohexol in patients developping or not acute kidney injury
Time frame: 7 days
Link between plasma iohexol clearance and kindney injury markers
Time frame: 24 hours
Link between injury and/or functional kidney dammage and subsequent acute kidney injury
Time frame: 7 days
Link between plasma iohexol clearance and urinary metabolomic markers
Time frame: 24 hours
Comparaison of plasma iohexol clearance measured with 3 and 6 vs. 9 kinetic points
Time frame: 24 hours
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