Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation

Phase 4WithdrawnNCT02051075

Rambam Health Care Campus

Overview

Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Infertility

Interventions

PXN sperm treatmentBIOLOGICAL

immotile sperm activation with PXN

Sperm activation with PXN and oocyte activationBIOLOGICAL

Eligibility

Sex: ALLMin age: 20 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women up to 35 years of age * immotile sperm * At least 6 mature eggs Exclusion Criteria: * globozoospermia * "Freeze all" cycles because of OHSS risk.

Locations (1)

Rambam medical Center

Haifa, Israel, Israel

Outcomes

Primary Outcomes

Clinical pregnancy

Demonstration of fetal heart activity 1 month post oocyte retrieval.

Time frame: One month post oocyte retrieval

Secondary Outcomes

Fertilization rate

Normal, 2 pronuclei, zygote one day post ICSI

Time frame: One day post oocyte retrieval

Data from ClinicalTrials.gov

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