The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release. The investigators' hypothesis is that minocycline will reduce post-operative pain.
This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution. The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
131
RCT blinded placebo trial
RCT blinded placebo trial
Palo Alto VA
Palo Alto, California, United States
Time to Pain Resolution
the time until patient answers no pain at surgical site for three consecutive days
Time frame: up to 365 days
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