Reversal of General Anesthesia With Methylphenidate

Phase 2CompletedNCT02051452

Massachusetts General Hospital32 enrolled

Overview

The aim of this study is to investigate whether methylphenidate (Ritalin) can actively induce emergence from general anesthesia in patients having a pancreaticoduodenectomy (Whipple procedure), a pancreatectomy, or a prostatectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Post Operative Cognitive Dysfunction Emergence From Anesthesia

Interventions

MethylphenidateDRUG

SalineOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-75 years * American Society of Anesthesiologists classification 1 or 2 * Scheduled to undergo a pancreaticoduodenectomy or distal pancreatectomy at Massachusetts General Hospital Exclusion Criteria: * American Society of Anesthesiologists physical status classification of 3 or beyond.

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Number of Participants With Adverse Events

Recorded as a measure of safety and tolerability

Time frame: 12 months

Secondary Outcomes

Time to Emergence From General Anesthesia

Measured as the time from drug (MPH or saline placebo) administration to extubation

Time frame: 1-4 hours

Data from ClinicalTrials.gov

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