Induction of Donor-Specific Tolerance in Recipients of Live Donor Stem Cell Infusion (Compassionate Use)

Inclusion Criteria: * Patient must be between the ages of 18 and 65 years and meet the institution's criteria for renal transplantation for end-organ failure * Patient is receiving first renal transplant * Patient is receiving a renal transplant only * The crossmatch is negative between donor and recipient * Women who are of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours of initiating total body irradiation (TBI) and agree to use reliable contraception for 1 year following transplant * Potential donors who are women of child bearing potential must have a negative pregnancy test (urine test is acceptable) within 48 hours prior to receiving Granulocyte colony-stimulating factor (G-CSF) * No evidence of donor-specific antibody presently or historically Exclusion Criteria: * Clinically active bacterial, fungal, viral or parasitic infection * Pregnancy * Clinical or serologic evidence of viral infection which would preclude the recipient from receiving a kidney transplant * Previous radiation therapy at a dose which would preclude TBI * Positive crossmatch between donor and recipient * Evidence for immunologic memory against donor * BMI \>35 or \<18 * Re-transplant * Positive serologies for hepatitis B virus (HBV), hepatitis C virus (HCV), HIV