Pre/Term Milk Profiling

N/ACompletedNCT02052245

Société des Produits Nestlé (SPN)61 enrolled

Overview

This study aims for an in-depth characterization of human milk of mothers who delivered prematurely to decipher differences with milk of mothers who delivered at the expected term, with a particular focus on milk proteins

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preterm Milk Term Milk

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Having obtained informed consent * Group 1 (term delivery): Gestational age between 37 0/7 and not above 41 6/7 weeks * Group 2 (preterm delivery): Gestational age between 28 0/7 and 32 6/7 weeks * Age: Mother ≥ 18 years old * Partial or total breast feeding * Having a freezer compartment at home (approx. -18°C) * Good understanding of the French language Exclusion Criteria: * Suffering from diabetes (type I or II) before pregnancy * Alcohol consumption: more than 1 standard drink / day * Drug addicted * Subject who cannot be expected to comply with the study procedures. * Currently participating in an interventional therapeutic clinical trial

Locations (1)

Clinic of neonatology - Avenue Pierre Decker 2

Lausanne, Switzerland

Outcomes

Primary Outcomes

Quantification of total protein concentration in human milk

Time frame: from delivery, up to 4 months

Secondary Outcomes

Quantification of total lipids and carbohydrates

Time frame: From delivery, up to 4 months

Determination of Calcium and Phosphorous content

Time frame: From delivery, up to 4 months

Determination of peptide profiles and content

Time frame: From delivery, up to 4 months

Determination of miRNA content

Time frame: From delivery, up to 4 months

Data from ClinicalTrials.gov

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