A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LFX453

Inclusion Criteria: * Healthy male and female subjects of non-childbearing potential, 18 to 65 years of age inclusive (at the time of the screening visit), and in good health as determined by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests at screening. * Male subjects must agree to total abstinence from male:female intercourse or agree to use a condom during drug dosing and for four weeks after dosing has stopped. Exclusion Criteria: * History of serious allergic reaction to any drug. * History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes. * History of any atopic dermatitis (only within the last 2 years), autoimmune disease, psoriasis or erythema multiforme. * Presence of skin disease (e.g. warts) or skin features on treatment areas that may affect local tolerability or the ability of the investigator to evaluate local tolerability. * History of heart failure, left ventricular dysfunction or known family history or known presence of long QT syndrome. * A history of clinically significant ECG abnormalities, or any of the following ECG abnormalities at screening or baseline: * 2nd or 3rd degree AV-block * PR \> 200 msec * QRS complex \> 120 msec * QTcF \> 450 msec (males) * QTcF \> 460 msec (females) * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test. * Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant.