Utility of Presepsin in Distinguishing Between Sepsis and SIRS

Sepsis/SIRS Patients Inclusion Criteria: * Male or female aged ≥ 21 years * Appropriate clinical data to enable classification into sepsis or SIRS * Written informed consent by the patient or legally authorized representative * Critical illness consistent with SIRS or sepsis, to be enrolled within 18 hours of presentation Exclusion Criteria: * No informed consent * Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a hematocrit \< 20% Control Inclusion Criteria: * Male or female aged ≥ 21 years * Does not meet clinical criteria for sepsis or SIRS * Written informed consent by the patient or legally authorized representative Exclusion Criteria: * No informed consent * Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a hematocrit \< 20% End Stage Renal Disease Inclusion Criteria: * Male or female aged ≥ 21 years * Documented diagnosis of end stage renal disease currently undergoing dialysis * Does not meet clinical criteria for sepsis or SIRS * Written informed consent by the patient or legally authorized representative Exclusion Criteria: * No informed consent * Unacceptable risk imposed by extra blood sampling, such as by gross hemorrhage with a hematocrit \< 20%