A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers

Inclusion Criteria: * Healthy Japanese adult males and females aged 20 to 65 years, inclusive (The subject was born in Japan and has lived outside of Japan for \<10 years, and subject's biological parents and grandparents are fully Japanese and were born in Japan); * Subjects who are healthy as determined by clinical assessments; * Females subjects must be of non-childbearing potential; * Males with partners of child-bearing potential, must agree to use appropriate contraception. Exclusion Criteria: * Subjects with a history of serious mental illness; * Subjects who have a clinically relevant medical or surgical history; * Subjects with a positive screen for alcohol or drugs of abuse; * Subjects with safety laboratory test results deemed clinically significant; * Subjects with known hepatitis B surface antigen (HBsAg), hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection; * Subjects who have received an investigational agent within the 3 months prior to study entry.