Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease

* INCLUSION CRITERIA: For subjects with lung diseases: * Men and women age 40-80 years * Smokers with greater than or equal to 10 pack-year history of ever-smoking EXCLUSION CRITERIA: For subjects with lung diseases: Subjects will be excluded from the study if they meet one or more of the following criteria: * Subjects who are under the age of 40 or over 80 years old * Women who are pregnant or lactating * Have known allergies to lidocaine or medications used for moderate sedation * Active coronary artery disease * Cerebral-vascular accident within the past 12 months * Active anticoagulation * Active infections * Cancer, or a history of cancer within the previous 5 years of screening (other than adequately treated cutaneous basal cell, squamous cell carcinoma, excised melanoma, or carcinoma in situ of the uterine cervix with no evidence of recurrence). * Poorly controlled chronic diseases * Unable to provide consent * Impaired renal function (including dialysis) * Contraindications to MRI scan including: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing * pre-existing medical conditions, including a likelihood of developing seizures or anxiety disorders such as claustrophobia, panic attacks or any psychiatric disorder INCLUSION CRITERIA: For Non-Smoking Controls * Men and women age 40-80 years * No prior history of smoking (this is a non-smoking cohort) EXCLUSION CRITERIA: For Non-Smoking Controls * Subjects who are under the age of 40 or over 80 years old * Women who are pregnant or lactating * Have known allergies to lidocaine or medications used for moderate sedation * Active coronary artery disease * Cerebral-vascular accident within the past 12 months * Active anticoagulation * Active infections * Cancer, or a history of cancer within the previous 5 years of screening (other than adequately treated cutaneous basal cell, squamous cell carcinoma, excised melanoma, or carcinoma in situ of the uterine cervix with no evidence of recurrence). * Poorly controlled chronic diseases * Unable to provide consent * Impaired renal function (including dialysis) * Contraindications to MRI scan including: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing * pre-existing medical conditions, including a likelihood of developing seizures or anxiety disorders such as claustrophobia, panic attacks or any psychiatric disorder INCLUSION CRITERIA For Smoking Controls * Men and women age 40-80 years * Subjects who have a prior smoking history EXCLUSION CRITERIA For Smoking Controls * Subjects who are under the age of 40 or over 80 years old * Women who are pregnant or lactating * Have known allergies to lidocaine or medications used for moderate sedation * Active coronary artery disease * Cerebral-vascular accident within the past 12 months * Active anticoagulation * Active infections * Cancer, or a history of cancer within the previous 5 years of screening (other than adequately treated cutaneous basal cell, squamous cell carcinoma, excised melanoma, or carcinoma in situ of the uterine cervix with no evidence of recurrence). * Poorly controlled chronic diseases * Unable to provide consent * Impaired renal function (including dialysis) * Contraindications to MRI scan including: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing * pre-existing medical conditions, including a likelihood of developing seizures or anxiety disorders such as claustrophobia, panic attacks or any psychiatric disorder